RosettaCommons Blog

Source: https://www.destinationhotels.com/suncadia-resort/photo-and-video-gallery We are pleased to announce that Summer RosettaCon will be held at Suncadia Resort in Washington from August 5 - 9, 2024. The conference will start on the late afternoon (4-5 pm) of Monday, and will finish on Friday morning after breakfast with the usual hike / activity day. Pre-RosettaCon will not take place as a separate meeting as the technical talks, discussions and tutorials will be incorporated into the program.  REGISTRATION Registration fees support conference sustainability; this fee is non-refundable and is one mechanism to reduce last minute cancellations and preserve our community resources. Note that the early registration deadline is June 15, 2024. Registrations after this date will incur a higher registration fee.  Please register at www.rosettacon.org . For the first time, all registrations will go through the same interface.  If you need a letter of invitation to apply...

The Winter RosettaCon organizers want to thank Liberum Bio for sponsoring the experimental validation of the designs that they carried out in 8 days starting from digital sequences! Liberum Bio produces proteins at high yields in cell-free systems at a fraction of the usual cost and time via highly engineered strains and state-of-the art reaction mixtures. At Winter RosettaCon 2024 in Boston, the Rosetta Commons in partnership with Liberum Biotech hosted the inaugural Winter Protein Design Games , focusing on the design of Tobacco Etch Virus (TEV) protease variants. TEV protease is commonly used as a tool for sequence-specific protein cleavage, facilitating the purification of proteins without affinity tags. The competition challenged cross-institutional participating teams to engineer TEV proteases that exhibited enhanced substrate cleavage efficiency over the wild-type enzyme.  The competition was straightforward: design TEV protease variants that outperform the wild type in cl...

Dear Rosetta community, Scientists in our community led an effort to develop a framework for the responsible development of AI tools for the life sciences. By establishing a framework of guiding principles, we're at the forefront of promoting safety, security, and ethical responsibility in the development of AI tools. Our commitment deeply embeds biosecurity and ethical considerations into AI advancements, advocating for openness and global cooperation to tackle the pressing challenges of health, energy, and environmental sustainability. This endeavor not only steers AI technology towards responsible growth but also aims to spark breakthroughs that benefit humanity at large. This voluntary commitment has been signed by 154 leading scientists from 28 countries, including Nobel laureate of 2018 Frances Arnold, Microsoft's Chief Scientific Officer Eric Horvitz, the 2018 Turing award winner Yann LeCun, and the Former White House Senior Director for Global Health Security and Biodef...

Hello friends of Rosetta, We're thrilled to announce an exciting new chapter in our community's journey! After 20 years of wonderful memories at the Sleeping Lady for our annual summer conference, we're moving to a new venue in 2024. As part of our journey of growth and exploration, we are embarking on a new adventure at the Suncadia Resort , outside of Seattle. Our community's evolution is a story of expanding horizons and embracing new possibilities. Suncadia Resort, with its state-of-the-art facilities and size, aligns perfectly with our commitment to growth, accessibility, inclusivity and innovation. This move is a way to test new waters while remaining true to our roots. It's an opportunity to explore new avenues, just as we encourage innovation and new ideas in our field. The Sleeping Lady will always hold a special place in our hearts, and the decision to try Suncadia Resort was made with a spirit of adventure and curiosity.  Join us from Aug 5-9, 2024 at Sun...

By Camille Mathis The FoR Task Force would like to share this update with the Rosetta Commons community. One year ago, at the start of 2022, the Rosetta board asked our group to explore open-sourcing Rosetta in order to adapt to the changing landscape and rapid developments in our field. Over the past year, starting with presentations on open-sourcing ideas to the TeleCon group and the Board, the work evolved to focus more broadly on the Future of Rosetta. This pivot was determined to be an essential prerequisite for realistic and thoughtful conversations about open source feasibility. The efforts of the team included a proposal on the future organizational structure and fiscal sponsorship, a town hall meeting to capture community perspectives on the proposal, a vote by the Board to endorse the revised proposal, discussions at RosettaCon, and formation of committees to carry out the next stages of visioning and capacity building for our community. To reference past FoR activities, see ...

Hello Rosetta community and friends of Rosetta,   We wanted to give you a brief monthly update about the things that are going on in the Rosetta community, especially with respect to the committees but also other things that are happening. If you'd like to join any of the committees, please get in touch with the respective chair. If you'd like to post anything to the November newsletter, please email Julia ( Julia.koehler.leman@gmail.com ).   Best, FoR   NSF POSE Award Phase I awarded The Future of Rosetta task force is pleased to report that we have been awarded an NSF Phase I Pathways to Enable Open-Source Ecosystems (POSE) award (PI: King, Co-PIs: Gray and Siegel)! There are two phases for POSE awards. Phase I provides $300,000 for 1 year to evaluate the feasibility of and develop a plan for migrating existing scientific software projects to open source. This aligns perfectly with the scoping and planning discussions we are having as a community right now. Phase II awards ...