De novo proteins and where to find them - RosettaCon 2022

By Kieran Didi There has been a lot happening recently in protein design, and it is easy to get lost in the daily flood of new papers and exciting ideas (for an overview of current models and approaches see this review which includes a great model table ). In such situations, it often helps to step back for a second, look at the bigger picture and chat to people about what is happening and what the future might hold. Luckily, RosettaCon was happening this August and provided a venue for exactly that: chat to people about protein design and fascinating ideas! In this post I want to highlight some presentations from the conference that I think are representative of some broader directions in the field.  Scaffolding protein motifs using Deep Learning - (Baker Lab, IPD, UW) While complete de novo design of proteins is still the holy grail of the field, in practice you often want to incorporate a motif  known from nature into a new custom-made scaffold. This motif-scaffolding problem

October update from Future-of-Rosetta task force

Hello Rosetta community and friends of Rosetta,   We wanted to give you a brief monthly update about the things that are going on in the Rosetta community, especially with respect to the committees but also other things that are happening. If you'd like to join any of the committees, please get in touch with the respective chair. If you'd like to post anything to the November newsletter, please email Julia ( ).   Best, FoR   NSF POSE Award Phase I awarded The Future of Rosetta task force is pleased to report that we have been awarded an NSF Phase I Pathways to Enable Open-Source Ecosystems (POSE) award (PI: King, Co-PIs: Gray and Siegel)! There are two phases for POSE awards. Phase I provides $300,000 for 1 year to evaluate the feasibility of and develop a plan for migrating existing scientific software projects to open source. This aligns perfectly with the scoping and planning discussions we are having as a community right now. Phase II awards

Proposal for the Future of Rosetta

Dear friends, colleagues, and supporters of Rosetta: I’m sure you are all aware of the rapid changes in our field of biomolecular structure prediction and design. Our Rosetta community has grown tremendously; our impact is rapidly extending into industry, materials, and the clinic; and deep learning is supercharging progress into the future.  I’m thrilled to share with you today a Proposal for the Future of Rosetta and to invite you to discuss it at our upcoming Town Hall : Thurs. June 30 Noon EDT = 9 AM PDT = 6 PM Europe = Midnight China Zoom link is on the wiki Here’s the history : Over the last several virtual RosettaCons, we have discussed the transformations in our field in “Future of Rosetta” breakout discussions. Then this past fall, a group of Rosetta scientists suggested that we should seriously consider shifting to a “free and open-source software (FOSS)” model to better position Rosetta as the standard platform for biomolecular modeling for all time. The Developer TeleCon

Repacking the Community

 ~ Contributed by the JEDI Committee Summer RosettaCon JEDI Session: Repacking the community At Summer RosettaCon 2021, we did not host an invited talk on Justice, Equity, Diversity, and Inclusion as we’ve done in previous meetings. Instead we facilitated a community-centered conversation entitled: Repacking the Community: defining what a Just, Equitable, Diverse and Inclusive Rosetta community looks like and proposing how to get there . Our call to action encouraged all Rosetta Commons members to join us for a discussion structured for productivity to arrive at a shared vision . Herein we report on the outcomes of this session, and discuss the top community requests and how we’ve subsequently actioned around these calls with a new set of task forces within the JEDI group.  What we did First off, a brief description of the session to paint a picture that explains how we arrived at our conclusions. The session was an hour, we met over Zoom, no surprises there. Ashley presented sli