Exploring new grounds: Introducing Suncadia Resort for Summer RosettaCon 2024

Hello friends of Rosetta, We're thrilled to announce an exciting new chapter in our community's journey! After 20 years of wonderful memories at the Sleeping Lady for our annual summer conference, we're moving to a new venue in 2024. As part of our journey of growth and exploration, we are embarking on a new adventure at the Suncadia Resort , outside of Seattle. Our community's evolution is a story of expanding horizons and embracing new possibilities. Suncadia Resort, with its state-of-the-art facilities and size, aligns perfectly with our commitment to growth, accessibility, inclusivity and innovation. This move is a way to test new waters while remaining true to our roots. It's an opportunity to explore new avenues, just as we encourage innovation and new ideas in our field. The Sleeping Lady will always hold a special place in our hearts, and the decision to try Suncadia Resort was made with a spirit of adventure and curiosity.  Join us from Aug 5-9, 2024 at Sun

Future of Rosetta Task Force Update

By Camille Mathis The FoR Task Force would like to share this update with the Rosetta Commons community. One year ago, at the start of 2022, the Rosetta board asked our group to explore open-sourcing Rosetta in order to adapt to the changing landscape and rapid developments in our field. Over the past year, starting with presentations on open-sourcing ideas to the TeleCon group and the Board, the work evolved to focus more broadly on the Future of Rosetta. This pivot was determined to be an essential prerequisite for realistic and thoughtful conversations about open source feasibility. The efforts of the team included a proposal on the future organizational structure and fiscal sponsorship, a town hall meeting to capture community perspectives on the proposal, a vote by the Board to endorse the revised proposal, discussions at RosettaCon, and formation of committees to carry out the next stages of visioning and capacity building for our community. To reference past FoR activities, see

De novo proteins and where to find them - RosettaCon 2022

By Kieran Didi There has been a lot happening recently in protein design, and it is easy to get lost in the daily flood of new papers and exciting ideas (for an overview of current models and approaches see this review which includes a great model table ). In such situations, it often helps to step back for a second, look at the bigger picture and chat to people about what is happening and what the future might hold. Luckily, RosettaCon was happening this August and provided a venue for exactly that: chat to people about protein design and fascinating ideas! In this post I want to highlight some presentations from the conference that I think are representative of some broader directions in the field.  Scaffolding protein motifs using Deep Learning - (Baker Lab, IPD, UW) While complete de novo design of proteins is still the holy grail of the field, in practice you often want to incorporate a motif  known from nature into a new custom-made scaffold. This motif-scaffolding problem

October update from Future-of-Rosetta task force

Hello Rosetta community and friends of Rosetta,   We wanted to give you a brief monthly update about the things that are going on in the Rosetta community, especially with respect to the committees but also other things that are happening. If you'd like to join any of the committees, please get in touch with the respective chair. If you'd like to post anything to the November newsletter, please email Julia ( ).   Best, FoR   NSF POSE Award Phase I awarded The Future of Rosetta task force is pleased to report that we have been awarded an NSF Phase I Pathways to Enable Open-Source Ecosystems (POSE) award (PI: King, Co-PIs: Gray and Siegel)! There are two phases for POSE awards. Phase I provides $300,000 for 1 year to evaluate the feasibility of and develop a plan for migrating existing scientific software projects to open source. This aligns perfectly with the scoping and planning discussions we are having as a community right now. Phase II awards

Proposal for the Future of Rosetta

Dear friends, colleagues, and supporters of Rosetta: I’m sure you are all aware of the rapid changes in our field of biomolecular structure prediction and design. Our Rosetta community has grown tremendously; our impact is rapidly extending into industry, materials, and the clinic; and deep learning is supercharging progress into the future.  I’m thrilled to share with you today a Proposal for the Future of Rosetta and to invite you to discuss it at our upcoming Town Hall : Thurs. June 30 Noon EDT = 9 AM PDT = 6 PM Europe = Midnight China Zoom link is on the wiki Here’s the history : Over the last several virtual RosettaCons, we have discussed the transformations in our field in “Future of Rosetta” breakout discussions. Then this past fall, a group of Rosetta scientists suggested that we should seriously consider shifting to a “free and open-source software (FOSS)” model to better position Rosetta as the standard platform for biomolecular modeling for all time. The Developer TeleCon