RosettaCommons Blog

We are excited to announce that Andreas Petrides is joining us at OMSF as the new Foldit Software Engineer. Andreas brings a wealth of experience and a fresh perspective to our team, making him a valuable addition to the Foldit project. Andreas holds a Bachelor of Science in Computer Engineering and Computer Science from Northeastern University and has over three years of experience in full-stack development. His technical proficiency spans across multiple programming languages, including C++, Python, JavaScript, and Ruby. Andreas has spent the last few years working on Foldit. This experience coupled with his strong background in software development, positions him perfectly to lead the integration of Foldit into web and mobile environments. Prior to joining us, Andreas worked for the Foldit team via UMass Dartmouth, where he contributed to the development and optimization of the Foldit game client. Among his accomplishments during this time were the addition of several new tools such

As a community, we aim to maximize the benefits and minimize the potential for harm of tools used for biomolecular design. We recognize that doing so will require a clear theoretical understanding of the benefit-risk profiles of our tools, and of how their development fits in the landscape of technological advancements and policy development. To this end, Rosetta Commons has welcomed Samuel Curtis as our inaugural Rosetta Commons Biosecurity Fellow. In this capacity, Sam will conduct research on these topics within the Rosetta Commons community and coordinate convenings between protein design community members and biosecurity policy experts to support better-informed policy decision-making. Sam earned a BA in Biochemistry, Biophysics, and Molecular Biology from Whitman College and an MSc in Global Affairs with Outstanding Distinction from Tsinghua University through the Schwarzman Scholars program. Prior to joining Rosetta Commons, Sam worked in AI policy for four years at a nonprofit,

Dear members of the Rosetta Community, The Rosetta Commons Board is excited to announce a significant milestone in the evolution of our community and a step on our path toward the Future of Rosetta. We have created a non-profit organization, the Rosetta Commons Foundation, which has established a wholly-owned subsidiary company called Levitate Bio. Levitate Bio provides cloud-based automated protein modeling and design protocols using AI & Rosetta, available through annual subscriptions. With a mission similar to the Rosetta Commons, the Rosetta Commons Foundation aims to foster a collaborative community that contributes to knowledge and tools for computational modeling and design of biological macromolecules. Appointed by the Rosetta Commons Board, the Foundation’s initial Board currently consists of Jeff Gray, Julia Koehler Leman, and David Nannemann. We expect this leadership structure to evolve soon, with a more permanent Board structure announced in due course. What is unique

Source: https://www.destinationhotels.com/suncadia-resort/photo-and-video-gallery We are pleased to announce that Summer RosettaCon will be held at Suncadia Resort in Washington from August 5 - 9, 2024. The conference will start on the late afternoon (4-5 pm) of Monday, and will finish on Friday morning after breakfast with the usual hike / activity day. Pre-RosettaCon will not take place as a separate meeting as the technical talks, discussions and tutorials will be incorporated into the program.  REGISTRATION Registration fees support conference sustainability; this fee is non-refundable and is one mechanism to reduce last minute cancellations and preserve our community resources. Note that the early registration deadline is June 15, 2024. Registrations after this date will incur a higher registration fee.  Please register at www.rosettacon.org . For the first time, all registrations will go through the same interface.  If you need a letter of invitation to apply for a U.S. visa, c

We are pleased to announce registration has opened for our 2024 Rosetta Workshop to be held July 22-24 in person at Vanderbilt University in Nashville, TN. The Vanderbilt Rosetta Workshop is designed to be an introduction to the Rosetta macromolecular modeling suite, focusing on a practical introduction to common Rosetta protocols. Registration for the workshop is on a first-come-first-served basis and is limited to 15 participants. Please register as soon as possible since spots fill quickly.   Participants are responsible for their own travel and accommodation arrangements. We have a block of rooms reserved at a discounted rate, and this information will be shared once registration is completed. For more information, and to register for the workshop, please visit  https://meilerlab.org/rosetta- workshop-summer-2024/ Questions can be directed at Rocco Moretti.

  Dear Rosetta Community, We are thrilled to announce the winners of our recent Science Image Contest! The response we received was great, with an array of breathtaking images showcasing the beauty and complexity of our communities' scientific research. After much deliberation, we have selected the top three submissions that stood out for their creativity and visual impact. Without further ado, let's congratulate our winners: 1st Place: Tom Schlegel - $500 Tom's image captivated us with its stunning detail and artistic composition. Congratulations, Tom, on your well-deserved first-place win! Colorful blender rendering of the lumazine synthase from the hyperthermophile Aquifex aeolicus. 2nd Place: Ian Haydon - $300 Ian's submission impressed us with its striking visuals and unique perspective. His image effortlessly combines artistry with science. Congratulations, Ian, on securing second place! Analogous to perfectly straight, twist-free pieces of lumber, this new class

The Winter RosettaCon organizers want to thank Liberum Bio for sponsoring the experimental validation of the designs that they carried out in 8 days starting from digital sequences! Liberum Bio produces proteins at high yields in cell-free systems at a fraction of the usual cost and time via highly engineered strains and state-of-the art reaction mixtures. At Winter RosettaCon 2024 in Boston, the Rosetta Commons in partnership with Liberum Biotech hosted the inaugural Winter Protein Design Games , focusing on the design of Tobacco Etch Virus (TEV) protease variants. TEV protease is commonly used as a tool for sequence-specific protein cleavage, facilitating the purification of proteins without affinity tags. The competition challenged cross-institutional participating teams to engineer TEV proteases that exhibited enhanced substrate cleavage efficiency over the wild-type enzyme.  The competition was straightforward: design TEV protease variants that outperform the wild type in cleavi